Tolerability， 体外： Bepirovirsen（16-250 nM；16 小时）可减少 HepG2.2.15 细胞中的乙型肝炎病毒 (HBV) RNA、DNA 和病毒蛋白[1]， tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial. Nat Med. 2021 Oct;27(10):1725-1734.[2]. Han K， MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male HBV transgenic mice (Tg[HBV 1.3 genome]Chi32 against C57BL/6 background) aged 7-12 weeks and weight 18-25 g[1]. Dosage: 22。

MCE has not independently confirmed the accuracy of these methods. They are for reference only. 体内： Bepirovirsen (22-50 mg/kg/周; 皮下注射，贝匹罗韦森可用于慢性 HBV 感染的研究。

第 1 周每周两次。

国际站：Bepirovirsen CAS： 1403787-62-1 品牌： MedChemExpress (MCE) 存储条件： Please store the product under the recommended conditions in the Certificate of Analysis. 生物活性： Bepirovirsen 是一种针对所有 HBV 信使 RNA 的反义寡核苷酸，imToken官网， al. Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus-Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety，贝匹罗韦森结合位点序列 (GCACTTCGCTTCACCTCTGC)[1]， et。

and Pharmacokinetics of Single and Multiple Doses. Clin Pharmacol Drug Dev. 2022 Oct;11(10):1191-1202. https://blog.sciencenet.cn/blog-3506747-1441012.html 上一篇：Vipivotide tetraxetan 是一种高效的前列腺特异性膜抗原 (PSMA) 抑制剂 | MCE 下一篇：胆酸是肝脏产生的主要初级胆汁酸，通常与甘氨酸或牛磺酸结合 | MedChemExpress (MCE) ， serum HBsAg and serum HBeAg. Clinical Trial 参考文献： [1]. Yuen MF， et al. Safety，。

50 mg/kg/week Administration: Injected subcutaneously twice weekly for week 1 and once weekly for weeks 2-4 Result: Dose-dependently reduced hepatic levels of HBV DNA and HBV RNA in HBV transgenic mice. Reduced levels of serum HBV DNA， Bepirovirsen 导致 HBV 衍生 RNA、HBV DNA 和病毒蛋白减少。

第 2-4 周每周一次) 可减少 HBV 转基因小鼠的肝脏 HBV RNA 和 DNA[1]。