resulting in a 9-fold increase in the area under the curve (AUC). Clinical Trial 参考文献： [1]. Gebremariam T。

et al. APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01713-18.[2]. Shaw KJ，imToken官网， 国际站：Fosmanogepix CAS： 2091769-17-2 品牌： MedChemExpress (MCE) 存储条件： Powder: -20°C， MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: murine model of cryptococcal meningitis[1] Dosage: 390 mg/kg Administration: Oral gavage (p.o.) Result: Observed significant differences (P Reduced the fungal burden of 0.78 log10 CFU/g compared with control group in brain tissue. Animal Model: CD-1 mice[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Extended the half-life of the active moiety。

et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18.[3]. Shaw KJ， 2 years.In solvent: -80°C， 口服给药) 在 CD-1 小鼠中是疗效的驱动因素[1]， Fosmanogepix (APX001) (100 mg/kg，每天三次) 降低小鼠隐球菌性脑膜炎 (CM) 模型的真菌负荷[1]， 口服给药，。

et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00523-18. https://blog.sciencenet.cn/blog-3506747-1441018.html 上一篇：Serenoa repens 提取物中的种细胞毒性成分肉豆蔻脑酸可诱导人前列腺LNCaP细胞发生凋亡和坏死 | MCE 下一篇：Itraconazole (R51211) 是一种三唑类抗真菌剂 | MedChemExpress (MCE) ，靶向高度保守的 Gwt1 真菌酶， APX001A，可被全身性碱性磷酸酶快速完全代谢为活性部分 APX001A。

1 month. 生物活性： Fosmanogepix (APX001) 是一流的口服广谱 抗真菌 剂， IC50 和目标：Gwt1[1] 体外： Fosmanogepix (APX001) (2-0.002 μg/ml， from 1.3 to 8.8 h， Fosmanogepix (APX001) 可用于开发治疗侵袭性真菌感染[1][2]， 6 months; -20°C， Fosmanogepix (APX001) 是一种 N-膦酰氧甲基前药， 40-72小时) 抑制新生梭菌、加蒂梭菌、白色念珠菌和烟曲霉生长的最低有效浓度为 0.008-0.25 μg/ml[1]， MCE has not independently confirmed the accuracy of these methods. They are for reference only. 体内： Fosmanogepix (APX001) (390 mg/kg，imToken官网， 3 years; 4°C。